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My life with lupus
nephritis is complicated

LUPKYNIS® helps me
focus on the fight

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97% of the time*, patients paid less than $10 for their LUPKYNIS prescription.

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*97% of the shipments of LUPKYNIS delivered cost the patient $10 or less. These are patients on commercial insurance, Medicaid or Medicare from January 2022 to December 2022.

LUPKYNIS is the 1st FDA-approved oral treatment specifically for lupus nephritis

LUPKYNIS works by helping to stop the attack of lupus nephritis, while protecting the kidneys from irreversible damage caused by this serious disease.

In clinical trials, LUPKYNIS helped control lupus nephritis with low-dose steroids.

Lupus nephritis is an attack on the kidneys caused by lupus

Lupus nephritis is a common and serious complication that about 1 out of 2 people living with lupus may go on to develop. If left untreated, lupus nephritis often leads to serious health problems, permanent kidney damage, and even kidney failure.

Stay Informed

Sign up for the latest LUPKYNIS news and get more information about Aurinia Alliance®, our personalized support program for people who are taking LUPKYNIS. You can also request to be contacted by an Aurinia Alliance Nurse Case Manager to help you enroll in the program and connect you with other services like our copay program for eligible commercial patients.

Important Safety Information

LUPKYNIS® (voclosporin) can cause serious side effects, including:

  • Increased risk of cancer. People who take LUPKYNIS have an increased risk of getting some kinds of cancer, including skin and lymph gland cancer (lymphoma). Limit and avoid exposure to sunlight and UV light such as tanning machines. Wear protective clothing and use a sunscreen.
  • Increased risk of infection. LUPKYNIS is a medicine that affects your immune system. LUPKYNIS can lower the ability of your immune system to fight infections. Serious infections can happen in people taking LUPKYNIS that can lead to hospitalizations and can cause death. Call your healthcare provider right away if you have symptoms of an infection such as fever, sweats or chills, cough or flu-like symptoms, muscle aches, or warm, red, or painful areas on your skin.

Do not take LUPKYNIS with medicines known as strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and clarithromycin, or if you are allergic to any of the ingredients in LUPKYNIS. You should not eat grapefruit or drink grapefruit juice while taking LUPKYNIS.

Before you use LUPKYNIS, tell your healthcare provider about all your medical conditions, including if you:

  • Plan to receive any vaccines. You should not receive any live vaccines during treatment with LUPKYNIS. Other vaccines may not work as well during treatment with LUPKYNIS.
  • Have or have had liver, kidney, or heart problems.
  • Have high blood pressure.
  • Are pregnant or plan to become pregnant or are breastfeeding or plan to breastfeed when taking LUPKYNIS. When taking LUPKYNIS in combination with mycophenolate mofetil, read the Medication Guide for mycophenolate mofetil for important pregnancy information. These medicines can harm your unborn or breastfed baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LUPKYNIS may affect the way other medicines work, and other medicines may affect how LUPKYNIS works.

LUPKYNIS may cause serious side effects, including:

Kidney problems. Kidney problems are common side effects of LUPKYNIS and may be serious. Your healthcare provider may do certain tests to check your kidney function while you take LUPKYNIS.

High blood pressure. High blood pressure is a common side effect of LUPKYNIS and may be serious. Your healthcare provider will monitor your blood pressure while you take LUPKYNIS and may ask you to check your blood pressure at home.

Nervous system problems. Nervous system problems are a common side effect of LUPKYNIS and may be serious. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of these symptoms while taking LUPKYNIS:

  • confusion
  • changes in alertness
  • muscle tremors
  • numbness and tingling
  • headache
  • seizures
  • vision changes

High levels of potassium in your blood. Your healthcare provider may do certain tests to check your potassium levels while you take LUPKYNIS.

A serious heart rhythm problem (QT prolongation).

Severe low red blood cell count (anemia). Your healthcare provider may check your labs while using LUPKYNIS.

The most common side effects of LUPKYNIS are diarrhea, headache, cough, urinary tract infection, stomach pain, heartburn, and loss of hair (alopecia).

These are not all the possible side effects of LUPKYNIS. For more information, ask your healthcare provider. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to www.fda.gov/medwatch.

What is LUPKYNIS?

LUPKYNIS is a prescription medicine used with other medicines to treat adults with active lupus nephritis. LUPKYNIS should not be taken with a medicine called cyclophosphamide. Talk with your healthcare provider if you are not sure if you take this medicine.

Please see Prescribing Information, including Boxed Warning, and Medication Guide for LUPKYNIS.